San Antonio Medical Center Real Estate For Sale

6 Beds ⋅ 8 Baths ⋅ 2014305 MLS ⋅ ACTIVE Status

Behind private gates, a winding drive disappears beneath mature trees and opens to more than six acres of private grounds, a 2.5-acre lake, pool and tennis court-remarkably located within the city. Beyond its beauty, the lake serves as the water source for irrigating the grounds, making the property's extensive landscaping remarkably cost-effective to maintain. This distinguished French-inspired estate offers an extraordinary sense of seclusion, pairing timeless architecture with refined modern luxury. Manicured gardens and lush landscaping create an idyllic approach to the residence, where soaring ceilings, graceful archways and expansive windows reflect the romance of the French countryside while framing captivating views of the surrounding grounds. Elegant, serene and truly one of a kind, this exceptional property presents a rare opportunity to enjoy the scale and privacy of a private retreat without sacrificing the convenience of city living.

7 Lazy Hollow, San Antonio

$1,990,000

2021345 MLS ⋅ NEW Status

Prime commercial opportunity with a strategic location near the Medical Center, USAA Headquarters, and UTSA, offering convenient access to IH-10 and Loop 410. The property features 75 total parking spaces, including 65 secure staff spaces with key-card access, plus additional visitor parking. C-3 zoning provides flexibility for a variety of uses, including medical, office, restaurant, and other commercial concepts. The property includes a spacious wooden patio with a covered bar/BBQ area, two conference rooms with glass windows overlooking the open first-floor area, ample interior lighting, and a comprehensive security camera system throughout the interior and exterior. A well-positioned property offering accessibility, functionality, and versatility for a range of commercial users.

7710 W Interstate 10, San Antonio

9643 Huebner Rd Unit 103 & 102, San Antonio

$1,850,000

4 Baths ⋅ 2014690 MLS ⋅ ACTIVE Status

9643 Huebner Road, San Antonio, TX 78240, a 5,924-square-foot medical office/business property strategically located in the heart of San Antonio's South Texas Medical Center. The property consists of two combined suites offering a versatile configuration for both investors and owner-users. Unit 103 encompasses approximately 3,614 square feet and features a traditional medical office layout with exam rooms, reception and patient waiting areas, administrative space, and private offices. Unit 102 offers approximately 2,310 square feet with a more open floor plan, providing flexibility for an owner-user, medical practice, or future tenant. The property currently features five exam rooms with sinks, six private office spaces, two reception/patient waiting areas, two administrative areas, a conference room, wet bar, break-room kitchenette, washer and dryer, one full bathroom, three half bathrooms, four HVAC units, and 8'+ ceilings. The property also provides 48 common parking spaces along with four private covered parking spaces. Located within the South Texas Medical Center, one of San Antonio's most significant healthcare, research, and medical employment hubs, the property benefits from proximity to major healthcare institutions including UT Health San Antonio, University Health, Methodist Healthcare, UT Health San Antonio MD Anderson Cancer Center, and the Audie L. Murphy VA Hospital. The Medical Center encompasses more than 900 acres, includes hundreds of medical offices, and supports more than 30,000 healthcare-related employees. (South Texas Medical Center. The Medical Center also attracts more than 5 million outpatient visitors and approximately 100,000 inpatient visitors annually, creating a substantial healthcare-oriented customer and employment base throughout the area. (South Texas Medical Center. 9643 Huebner Road offers an exceptional opportunity to acquire an established medical office property in a highly sought-after healthcare corridor, with existing medical infrastructure, flexible suite configurations, strong parking, and proximity to some of San Antonio's leading healthcare and research institutions.

9643 Huebner Rd Unit 103 & 102, San Antonio

$1,750,000

2 Beds ⋅ 3 Baths ⋅ 1891990 MLS ⋅ ACTIVE Status

Nestled within the prestigious gated community of Oak Hills Country Club, this exceptional 3.607-acre estate at 5351 Fredericksburg Road offers unparalleled luxury and privacy. The property features a stunning main residence built in 1922 and a charming guest house, both surrounded by majestic heritage live oaks and sprawling landscaped grounds. Enjoy sweeping views from multiple outdoor patios, perfect for entertaining or serene relaxation. Golf enthusiasts will delight in the private chipping greens and exclusive access to the community's gorgeous golf course, complemented by top-tier amenities including tennis courts, a clubhouse, and a sparkling pool. With ample attached garage space and a prime location in San Antonio's coveted Near Northwest located minutes from South Texas Medical Center, this estate combines sophisticated living with resort-style recreation, creating a rare opportunity for discerning buyers and developers.

5351 Fredericksburg, San Antonio

$1,720,000

2 Beds ⋅ 2 Baths ⋅ 1835400 MLS ⋅ ACTIVE Status

OCCUPIED & GATED. 2 Tracks, 1.29 Acres each, Total 2.58 Acres. Babcock Rd. Frontage 230 ft. Wide 491 ft. Length. Main House 2 bed, no closets, 2 bath, approx. 2076 sq. ft. Guest House 1 bed, 1 bath,1 living approx. 700 sq. ft. Property with Private Well Water, 2 RV Electric, Water and Sewer Hookups. Zoned Residential, Potential for Rezoning for Development.

6051 Babcock Rd, San Antonio

$1,650,000

1997121 MLS ⋅ ACTIVE Status

8931 Wurzbach Road is a rare opportunity to acquire a 5,971 SF freestanding commercial building situated on 0.855 acres in one of San Antonio's most established and high-traffic commercial corridors. Zoned C-3 General Commercial, the property offers exceptional flexibility for a wide range of retail, restaurant, medical, office, entertainment, and service-oriented uses. Formerly operated as a restaurant, the property features ample on-site parking with space for a drive-thru, strong visibility along Wurzbach Road, and convenient access to Interstate 10 within half a mile. The site benefits from a strategic position near the South Texas Medical Center, one of the largest healthcare hubs in Texas, as well as major employers and institutions, including USAA Headquarters. Surrounded by dense residential neighborhoods, established retail centers, hotels, and medical facilities, the property offers access to a substantial consumer base and workforce population. The location provides excellent connectivity to Fredericksburg Road, Loop 410, Downtown San Antonio, and Northwest San Antonio, making it well-suited for owner-users seeking a central location or investors pursuing repositioning and redevelopment opportunities.

8931 Wurzbach Rd, San Antonio

$1,450,000

4 Beds ⋅ 4 Baths ⋅ 2017741 MLS ⋅ ACTIVE Status

Lovingly maintained single-story Mid-Century Modern estate on 1.5 acres in Oak Hills with intact original character and city skyline views! Features vaulted ceilings, tile floors, custom stained-glass doors, and abundant natural light. Kitchen includes island seating and Sub-Zero refrigeration. Bedrooms offer custom built-ins and private courtyard views; the primary suite features skyline views. Beautifully landscaped grounds include a pool, fountain, gazebo, pool house with a bath/changing room, greenhouse, and a peaceful pond with waterfalls. Features a separate 5,000 sq ft building with an open-bay workshop, RV/car storage, ample parking, and fully climate-controlled 1 bed and 1.5 bath apartment and a dedicated office-ideal for multi-generational living or guests. Minutes from Oak Hills Country Club, Medical Center, and highways.

7142 Oakridge, San Antonio

$1,375,000

5 Beds ⋅ 6 Baths ⋅ 2012478 MLS ⋅ ACTIVE Status

One of a kind in both design and function, this distinctive residence offers an uncommon combination of luxury, warmth, expansive living spaces, and remarkable functionality, tucked into one of San Antonio's hidden established enclaves. Set on approximately .61 acres beneath mature trees, the home feels wonderfully secluded while remaining centrally located with convenient access throughout the city. Inside, the architecture creates something increasingly hard to find: generous, beautifully defined rooms that remain connected without sacrificing their individual purpose. A dramatic wall of windows visually connects four of the home's principal spaces, the kitchen, formal dining room, formal living room, and office, filling them with natural light and creating a continuous connection to the outdoor living areas. Thoughtful walk throughs between rooms and numerous French doors further enhance the flow, allowing everyday living and entertaining to move naturally from one space to another and outside. The kitchen sits at the heart of it all, equally suited for casual gatherings or more formal entertaining, with abundant cabinetry, workspace, storage, and easy access to both living areas and the backyard. Throughout the home, architectural details including tall and coffered ceilings, custom herringbone inlaid wood flooring, Saltillo tile, fireplaces, and expansive windows give each room its own character. Recent improvements have thoughtfully updated the home while preserving the details that make it unique, including a refreshed kitchen and cabinetry, quartzite countertops, updated lighting and plumbing fixtures, refinished and sealed parquet flooring, refreshed landscaping and landscape lighting, and an updated interior and exterior color palette. The primary suite is truly a private wing of the home. Separated from the additional bedrooms, it encompasses an expansive bedroom and bath, a private loft, and an adjoining office, den, or library with a beautiful fireplace. The office can function as part of the private suite or open to the surrounding living areas, while the primary bath even offers direct access to the backyard. Three ensuite bedrooms, including the primary, create exceptional flexibility for guests and multigenerational living. Outside, the home becomes an entertainer's retreat. Multiple gathering areas offer both shaded seating and sun filled spaces surrounding the pool and spa. Saltillo patios, wood decking, built in seating, mature trees, a raised Oklahoma flagstone sunning area with Texas star detail, and multiple access points from the interior create an effortless indoor and outdoor connection. The pool house adds a wet bar with beverage or wine refrigerator, bath, and separate storage room, while a custom playscape provides another dedicated outdoor space. Even the garage space offers possibilities. In addition to the attached garage, a tandem garage provides additional parking, storage, workshop potential, or an opportunity to explore conversion for another use. This is a home designed to entertain with style while providing the storage, organization, and function to do it exceptionally well. And when the entertaining is over, its many distinct living spaces offer something just as valuable: the ability to retreat to a favorite corner and enjoy the secluded luxury of home.

6 Sleepy Cove St, San Antonio

$1,329,000

2017710 MLS ⋅ ACTIVE Status

Versatile single-story medical or professional office building offering approximately 3,720 square feet on a prominent 0.53-acre corner lot. The thoughtfully designed interior features 14 private offices or treatment rooms, two executive suites-each with a private restroom-two public restrooms, an additional employee restroom, a spacious waiting area, private reception area, and large staff kitchen. Currently operating as a medical practice, the property is well suited for healthcare, wellness, dental, therapy, or other professional office uses. Conveniently located near San Antonio's Medical Center with easy access to I-10, major roadways, dining, and surrounding businesses. An excellent opportunity for an owner-user or investor seeking a functional property in an established professional area.

9518 Tioga Dr, San Antonio

$1,200,000

5 Beds ⋅ 6 Baths ⋅ 1990661 MLS ⋅ ACTIVE Status

A rare opportunity to own and revitalize an expansive estate in one of San Antonio's most coveted corridors. Offering 6,068 square feet of living space in a truly funcitonal tri-level home with lower level walkout access. The home showcases an exceptional combination of scale, privacy, architectural character, and versatility. The property features controlled access, a spacious backyard and gazebo, mature trees, and elevator access/entry. The third garage is complemented by an attached casita, offering flexibility for guests, extended family, or private accommodations. Inside, the home's generous living spaces showcase characteristics of its' generation, including wood coffered ceilings and a large living area with an adjoined wet bar, perfect for entertainment. Stone accents and wooden built-ins offer tremendous potential for restoration, personalization, or transformation. As a whole, 9218 Callaghan Rd. presents a unique opportunity to create something truly exceptional in a highly desirable San Antonio location. An incredible canvas for those with an exceptional vision. Estate offered AS-IS.

9218 Callaghan Rd, San Antonio

$1,200,000

1919146 MLS ⋅ ACTIVE Status

Exceptional Opportunity to Acquire a Commercial Property in the San Antonio Medical Center! Building & Zoning: Remodeled shell building (2025) with updated zoning to Neighborhood Commercial (NC) allowing for flexible uses Lot size: ~1 Acre with ingress from and egress to Old Babcock Rd, Building Sizes: 3000 sq. ft. shell building with utilities in place and a 400 sq ft storage two-story storage building Approved Plans: City-approved construction plans, new survey, and platting included Location: Prime area near major hospitals, USAA, UT San Antonio, La Cantera, The Rim, Medical Drive, local businesses, and key highways Potential Uses: Ideal for a variety of commercial ventures such as:-Medical or Dental Office-Law Firm or Professional Office-Coffee Shop, Bakery, Grocery, or QSR-Veterinary Clinic or Pet Grooming Features & Upgrades: 10-space asphalt parking lot completed (October 2025) Additional Options: Available for long-term lease, as well. This property offers flexibility, visibility, and is in a strategic location dense with residential, national retailers and restaurants, medical providers, and more, making it a perfect investment opportunity for a wide range of uses.

6395 Old Babcock, San Antonio

$1,199,000

4 Beds ⋅ 2 Baths ⋅ 1912159 MLS ⋅ ACTIVE Status

Set on 6.78 private acres, this unique estate combines elegance, versatility, and privacy at an impressive scale. Enclosed by full perimeter/privacy fencing, the property offers an ideal setting for a luxury residence, boutique retreat, or private family compound, delivering both lifestyle and investment potential. In addition to two separate residences, the estate features an industrial warehouse for additional storage or creative use, a rear dwelling with renovation or rebuild potential, and a picturesque wedding canopy and gazebo-perfect for celebrations, and outdoor entertaining. A sweeping circular drive with dual gated entrances creates a grand sense of arrival, leading to oak-shaded grounds, multiple patios, and an expansive resort-style pool with hot tub, ideal for gatherings and leisure alike. Inside, both residences highlight timeless architectural details, including hardwood floors, stone fireplaces, and spacious living areas. A chef's kitchen provides the ideal space for entertaining or everyday comfort, while a private well ensures efficient and sustainable upkeep for the entire property. With its prime location, unmatched amenities, and endless possibilities, 6472 Whitby Rd is more than an estate-it's a destination of its own, offering an extraordinary opportunity to live, entertain, and create.

6472 Whitby, San Antonio

$1,175,000

4 Beds ⋅ 3 Baths ⋅ 2003633 MLS ⋅ ACTIVE Status

Commanding San Antonio skyline views from inside and out from a variety of rooms, patios and elevations! Single-level living and an extensive renovation define this distinctive Oak Hills estate. Set on approximately 0.58 acre beneath mature trees with no mandatory HOA, the 4,136-square-foot home offers four bedrooms, 2.5 baths and substantial system upgrades only minutes from the Medical Center. The renovation extends well beyond finishes, fixtures and appliances and our pictures simply couldn't capture all areas touched. Key items include electrical rewiring and new interior panels, updated plumbing and gas lines, a five-ton Ruud condenser, new ducting and vents, low-E windows and sliding doors, added insulation, new drywall and flooring, cement soffits, roof shingles and decking replaced where needed, a gas fireplace and hydro jet sewer cleanout. Redesigned retaining walls and backyard steps. No details too large or two small! Combine all this with multiple patios, a circular drive, and the expansive grounds still offer room to imagine a pool, sport court, garden or an additional outdoor retreat. To truly grasp the presence and scale of this residence, a private tour is essential. City permits, inspections, testing and supporting documentation will be shared by the seller with offer submissions.

311 E Woodlake Dr, San Antonio

$1,160,000

4 Beds ⋅ 5 Baths ⋅ 1973283 MLS ⋅ ACTIVE Status

Sculptural Lines. Continental Spirit. Bespoke Living. Designed by DDL Architects and built by SW11 International Custom Home Builders, 4139 Cliff Oaks brings European modern design to Oak Hills, in the Medical Center area. Steel beams, walls of glass, and soaring ceilings define the interiors, finished with materials sourced from Europe. Mature oaks frame the views. The home sits in a private gated enclave with walking access to Oak Hills Country Club. Three courtyards with water and fire features offer room to entertain or unwind, and an indoor smart pool allows year-round swimming. At 4,009 square feet, it lives comfortably day-to-day and locks up easily when you travel. Experience one of San Antonio's most distinctive contemporary residences by scheduling your private tour today.

4139 Cliff Oaks St, San Antonio

$1,133,000

3 Beds ⋅ 3 Baths ⋅ 2003644 MLS ⋅ PRICE CHANGE Status

LOCATION LOCATION LOCATION!! Truly a once-in-a-lifetime opportunity! Stunning Builder's Home! 3,451 square feet of luxurious living with nearly 100 feet of frontage on the 17th fairway at the championship Oak Hills Country Club. Conveniently located right in the heart of the San Antonio Medical Center area with easy access to IH-10, 410. Fulfill your dreams of living on the links! Just walk out your back door! Golf cart path directly to the club house with full pro shop, fitness center, hard and clay tennis courts, pickleball courts, junior Olympic sized swimming pool, fine dining and a wealth of programming! DON'T MISS THIS ONCE IN A LIFETIME OPPORTUNITY!

5401 Fredericksburg, San Antonio

Medical Center Homes For Sale

Medical Center - San Antonio Homes For Sale